{"id":3614,"date":"2021-11-24T20:29:07","date_gmt":"2021-11-24T20:29:07","guid":{"rendered":"https:\/\/scian.cl\/scientific-image-analysis\/?p=3614"},"modified":"2021-11-24T20:29:08","modified_gmt":"2021-11-24T20:29:08","slug":"apical-contacts-stemming-from-incomplete-delamination-guide-progenitor-cell-allocation-through-a-dragging-mechanism-2","status":"publish","type":"post","link":"https:\/\/scian.cl\/scientific-image-analysis\/apical-contacts-stemming-from-incomplete-delamination-guide-progenitor-cell-allocation-through-a-dragging-mechanism-2\/","title":{"rendered":"Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism"},"content":{"rendered":"\n<p class=\"has-medium-font-size\"><em><span class=\"has-inline-color has-theme-palette-6-color\">eLife<\/span><\/em><\/p>\n\n\n<style>.wp-block-kadence-spacer.kt-block-spacer-_e089ce-cb .kt-block-spacer{height:60px;}.wp-block-kadence-spacer.kt-block-spacer-_e089ce-cb .kt-divider{border-top-width:1px;height:1px;border-top-color:#eee;width:80%;border-top-style:solid;}<\/style>\n<div class=\"wp-block-kadence-spacer aligncenter kt-block-spacer-_e089ce-cb\"><div class=\"kt-block-spacer kt-block-spacer-halign-left\" style=\"height:60px\"><hr class=\"kt-divider\" style=\"border-top-color:#eee;border-top-width:1px;width:80%;border-top-style:solid\"\/><\/div><\/div>\n\n\n\n<p>Pulgar E., Schwayer C., Guerrero N., L\u00f3pez L., M\u00e1rquez S, H\u00e4rtel S., Soto R., Heisenberg CP. And ML Concha<\/p>\n\n\n\n<p><strong>ABSTRACT<\/strong><br>The developmental strategies used by progenitor cells to endure a safe journey from their induction place towards the site of terminal differentiation are still poorly understood. Here we uncovered a progenitor cell allocation mechanism that stems from an incomplete process of epithelial delamination that allows progenitors to coordinate their movement with adjacent extra-embryonic tissues. Progenitors of the zebrafish laterality organ originate from the surface epithelial enveloping layer by an apical constriction process of cell delamination. During this process, progenitors retain long-term apical contacts that enable the epithelial layer to pull a subset of progenitors along their way towards the vegetal pole. The remaining delaminated progenitors follow apically-attached progenitors\u2019 movement by a co-attraction mechanism, avoiding sequestration by the adjacent endoderm, ensuring their fate and collective allocation at the differentiation site. Thus, we reveal that incomplete delamination serves as a cellular platform for coordinated tissue movements during development.<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.7554\/eLife.66483\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.7554\/eLife.66483<\/a><\/p>\n\n\n\n<p><br><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pulgar E., Schwayer C., Guerrero N., L\u00f3pez L., M\u00e1rquez S, H\u00e4rtel S., Soto R., Heisenberg CP. And ML Concha (2021) Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism. eLife 10:e66483<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"categories":[9],"tags":[],"class_list":["post-3614","post","type-post","status-publish","format-standard","hentry","category-publications-2021"],"_links":{"self":[{"href":"https:\/\/scian.cl\/scientific-image-analysis\/wp-json\/wp\/v2\/posts\/3614","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/scian.cl\/scientific-image-analysis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/scian.cl\/scientific-image-analysis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/scian.cl\/scientific-image-analysis\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/scian.cl\/scientific-image-analysis\/wp-json\/wp\/v2\/comments?post=3614"}],"version-history":[{"count":1,"href":"https:\/\/scian.cl\/scientific-image-analysis\/wp-json\/wp\/v2\/posts\/3614\/revisions"}],"predecessor-version":[{"id":3615,"href":"https:\/\/scian.cl\/scientific-image-analysis\/wp-json\/wp\/v2\/posts\/3614\/revisions\/3615"}],"wp:attachment":[{"href":"https:\/\/scian.cl\/scientific-image-analysis\/wp-json\/wp\/v2\/media?parent=3614"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/scian.cl\/scientific-image-analysis\/wp-json\/wp\/v2\/categories?post=3614"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/scian.cl\/scientific-image-analysis\/wp-json\/wp\/v2\/tags?post=3614"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}