Mechanisms of Developments

Lemus C, Palma K, Jara J, Härtel S and M Concha

The establishment of asymmetry in the embryonic zebrafish brain begins with the left-sided asymmetric positioning of the parapineal organ (PpO), an event that is required for further development of asymmetries in neighbouring diencephalic nuclei. Previous studies have shown that PpO asymmetric morphogenesis requires Nodal and Fgf8 dependent signalling but the cellular behaviours that are controlled by these signalling pathways are still unclear. Here we investigated these behaviours.