Radiation induced membrane effects in thymocyte apoptosis.

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Progress in Biophysics and Molecular Biology, (65), 89.

Härtel, S., & Diehl, H. A. (1996).

ABSTRACT
Purpose: The hypothesis shall be examined that the cell membrane fluidity of thymocytes is countercorrelated to their dose response of their radiation induced apoptotic cell death.Methods: Cell membrane fluidity is enhanced by xenobiotics or decreased by cholesterol insertion. The dose response for the radiation induced apoptotic death of thymocytes is measured cytoflowfluorometrically.Results: Membrane fluidity and radiation dose response of apoptotic cell death are counter-correlated.Conclusions: Thymocyte cell membrane fluidity is essentially connected to thymocyte apoptotic cell death. The membrane is supposed to be the primary target.

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