Cover Page in Reproduction, Fertility and Development Automated Analysis of sperm motility in WT and NPC2 -/- mice. Red, green, blue, and yellow colors mark progressive, slow, immotile, or hyperactivated sperm trajectories. Images by Susana Vargas, BNI, SCIAN-Lab, ICBM, University of Chile.
Spermatozoa from mice deficient in Niemann-Pick disease type C2 (NPC2) protein have defective cholesterol content and reduced in vitro fertilising ability. Busso D, Oñate-Alvarado MJ, Balboa E, Castro J, Lizama C, Morales G, Vargas S, Härtel S, Moreno RD and S Zanlungo.